Alfred Nzo is one of the 6 districts of Eastern Cape province of South Africa. The seat of Alfred Nzo is Mount Ayliff. The majority of its 801 344 people speak Xhosa.[4] The district code is DC44.

It is named after Alfred Baphethuxolo Nzo, a former secretary-general of the African National Congress and minister of foreign affairs in Nelson Mandela's cabinet from 1994 to 1999.